Endocrine Abstracts

Aims: Bening and malignant thyroid nodules are the most common lesions of endocrine glands. Some molecular markers; Mut-S homolog-2 (MSH2) and Mut-L-homolog-1 (MLH1) are the two of DNA repair proteins and metil guanin–DNA-metil transferase (MGMT) is the DNA repair enzymes have been studied. In this study, our aim is to evaluate MSH2, MLH1, and MGMT levels in papillary thyroid cancer (PTC), multinodular colloidal goitre (MNG), and chronic lymphocytic thyroiditis (CLT) and ...

A 75-year-old man presented to Emergency department with fever and 3 episodes of tonic clonic seizures. He had recent ear infection. He was intubated and ventilated and taken to ICU.He had CT head which was normal. Lumbar puncture results were consistent with Pneumococcal meningitis. He was treated with appropriate antibiotics.During recovery he had persistent hyponatremia. He was reviewed by Endocrine team and his TFT, cortisol an...

Introduction: The ectopic ACTH syndrome accounts for 12% of patients with Cushing’s syndrome. Its diagnosis and treatment remains a challenge. This especially true in patients with ectopic ACTH production.Case: We report the case of a 41-year-old man who presented with progressive muscle weakness in his arms and legs. He was found to be borderline hypertensive BP 145/92, cushingoid plethoric rounded face and mild proximal muscular weakness. His init...

Extradrenal paragangliomas can occur in individuals at any age although most arise in the fourth or fifth decade. Familial paragangliomas constitute approximately 10% of cases. These are part of a rare syndrome characterized by slow-growing tumors derived from paraganglia tissue. Recent years have brought significant progress in identifying the genetic etiology of this syndrome.Thirty-eight years old female was referred to the endocrine department by ENT...

Introduction: Phaeochromocytoma is a rare neuroendocrine tumour, with serious and potentially lethal cardiovascular complications. Cerebral haemorrhage is an unusual complication of phaeochromocytoma with <40 cases reported worldwide.Case: We report the case of a 29-year-old woman who presented with sudden onset of headache and collapse. CT Brain showed right sided frontal haemorrhage, her BP > 200/100, LVH on ECG and Echocardiography suggesting ...

Seventy six year old man presented with sudden onset headache for 3 days. He was seen by the GP and treated for migraine. But no improvement in his headache and he developed drooping of left eyelid and blurring of vision. No other neurological symptom.On examination left ptosis with normal visual fields to confrontation method. Initial differential diagnosis was isolated 3rd nerve palsy probably due to posterior communicating artery aneurysm. He was on a...

Sixty seven year old gentleman presented to eye clinic with blurring of vision in the left eye for 2 weeks. Patient was seen by Ophthalmologist and discharged home. Presented 3 weeks later with headache and blurring of vision. On examination no perception to light in the left eye and bitemporal hemianopia.His past history includes carcinoma prostate, diagnosed a year ago and had surgery and Radiotherapy. His recent PSA was normal. Bones scan showed no ev...

An 18-year-old male referred to endocrine department 3 years ago with symptoms of tremor in both hands and query thyrotoxicosis. Presenting TFTs showed raised T3 and T4 levels with normal TSH (FT4 – 45 pmol/l, FT3 – 3.3 pmol/l and TSH of 1.4 mU/l). There was family history of thyroid disease with both the patient’s father and grandmother diagnosed with overactive thyroid. Patient’s TFTs were reproduced with differ...

The link between exogenous steroid use and hypothalamo–pituitary–adrenal (HPA) axis suppression is well established. We present an unusual case where the use of an intra-oral steroid paste transiently obscured the diagnosis of Addison’s disease.A 45-year-old lady presented to hospital with a several week history of weight loss, nausea and vomiting, lethargy and postural dizziness. Physical examination was unremarkable except for hypotensio...

Background: Thyroid nodules (TN) are common. Their prevalence increases with age. A thyroid incidentaloma (TI) is defined as a non-palpable TN detected fortuitously during a radiological investigation performed for reasons unrelated to the thyroid gland. Although they are mostly benign, the risk of malignancy is estimated from 7% to 15% of nodules. The objective of this study is to investigate the characteristics of TI in a cohort of patients admitted in an internal medicine d...